Streptokinase

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Streptokinase resistance: when might streptokinase administration be ineffective?

OBJECTIVE (a) To develop an assay for streptokinase resistance. (b) To determine the prevalence of streptokinase resistance in patients presenting with acute myocardial infarction for the first time. (c) To determine the prevalence of streptokinase resistance in patients after exposure to streptokinase or streptococcal infection. DESIGN Open, prospective. PATIENTS 30 healthy volunteers. 40 ...

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Heberkinasa: recombinant streptokinase.

I would like to comment about Heberkinasa (recombinant streptokinase): one of the preparations included in the article written by Dr Hermentin et al. 1 The quality control system of the Center of Genetic Engineering and Biotechnology has been successfully evaluated by the World Health Organization and another International Regulatory Organizations. The biological activity of the Heberkinasa bat...

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Plasminogen Activation With Streptokinase

Background. Platelet activation occurs in vivo during pharmacologic thrombolysis and may contribute to recurrent thrombosis. Plasmin does not directly activate platelets except at high concentrations; thus, the mechanisms for platelet activation during thrombolysis remain undefined. Increases in thrombin activity also occur in patients treated with fibrinolytic agents and may contribute to acti...

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The Streptokinase-plasminogen System

Human plasminogen, plasma, or serum increased the pathogenicity of six streptokinase-positive streptococcal strains for mice. Combinations of commercial streptokinase and plasminogen or streptokinase and plasma did not usually increase mouse mortality to a greater degree than did plasminogen or plasma alone, suggesting that the maximal effective amount of streptokinase was produced by the organ...

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Streptokinase for aortic thrombosis.

A neonate developed complete thrombosis of the abdominal aorta after catheterisation of the umbilical artery. This was successfully treated with an intravenous infusion of streptokinase.

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ژورنال

عنوان ژورنال: Reactions Weekly

سال: 2021

ISSN: ['1179-2051', '0114-9954']

DOI: https://doi.org/10.1007/s40278-021-00042-z